|
|
|
- MbtH Protein Rv2377c:
The depicted structure represents the protein Rv2377c from Mycobacterium
tuberculosis, the pathogenic bacterial species that is the
causative agent of most cases of tuberculosis. Rv2377c is the
founding member of the MtbH family of proteins that are located
in a cluster of genes involved in nonribosomal peptide synthesis
of mycobactin. While the precise biological function of Rv2377c
and other MbtH-like proteins remain unknown, their association
with siderophore biosynthesis has identified these proteins as a
target for antibiotic development because siderophores are
crucial to iron regulation in the bacterium after infection.
For more information, please see the
Protein Data Bank entry
2khr.
|
|
