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E-mail submission of Target Requests
Applicants should e-mail a document containing the following information to target.request@sbri.org. Failure to include all of the requested information may results in a delay in consideration of the target request.
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Cover page: the applicant’s name, institution and contact information, as well as the target organism and proposed protein target.
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Target descriptionGene and protein names (and synonyms if necessary), coordinates within the genome, as well as the nucleotide and amino acid sequences and annotated function.
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Justification: A brief (one or two sentences) description of how determination of target structure will enhance research progress in the field. The justification may include reference to supporting experimental evidence and/or relevant literature, as well as the approximate size of the relevant scientific community.
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Comments: special information relevant to the proposed approach for structure determination (e.g. the importance of post-translational protein modifications, known ligands and their availability, previous attempts at either X-ray crystallography or NMR structure determination, and whether one of the centers is specifically requested). This information is optional, but may be of significant value in determining the appropriate protein production and structure determination pipeline(s).
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Resources:describing the availability of genetic material suitable for expression of the target protein, including any molecular clones already available.
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Confidentiality and intellectual property agreement: acknowledging that structures determined by the SSGCID will be submitted to the PDB and be part of the public domain.
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