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Participating Institutions
The SSGCID includes three Western Washington-based research organizations; Seattle BioMed, Emerald BioStructures, and the University of Washington; and the Pacific Northwest National Laboratory (operated by Battelle Memorial Institute) located in Richland, Washington.
This partnership represents a unique blending of academic, institutional, and industrial efforts with a history of producing technological advances and innovations, expertise in infectious diseases and drug development, and proven ability to work with challenging protein targets, employing state-of-the-art structural genomic research.
Click on the logos below for more information about each site.
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Seattle BioMed is responsible for the overall management for the SSGCID structure determination effort as well as protein purifications from bacterial expression systems and cloning, expression and purification of complexes and proteins produced in cell-free systems. |
PNNL provides equipment and expertise for NMR-based determination of the structures of a small number of proteins that cannot be solved by X-ray crystallography. |
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The UW PPG provides high-throughput cloning
and testing of target proteins in bacterial expression vectors, as
well as large-scale protein production and purification. |
Emerald's role in the SSGCID included gene construction and expression testing, large-scale protein production and purification; crystallization screening and production, pre-screening of crystals before they are sent for data collection at the synchrotron beam-lines, and structure determination using the resulting data. |
Other Partners
SSGCID is working closely with the other NIAID-funded center (CSGID).
This project is funded by the National Institute of Allergy and Infectious Diseases under Department of Health and Human Services Contract No. HHSN272200700057C.
