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Peer Reviewed Publications by SSGCID
Structural
characterization of a ribose-5-phosphate isomerase B from the
pathogenic fungus Coccidioides immitis.
Edwards, T.E., Abramov, A.B., Smith, E.R., Baydo, R.O., Leonard, J.T.,
Leibly, D.J., Thompkins K.B., Clifton, M.C., Gardberg, A.S., Staker,
B.L., Van Voorhis, W.C., Myler, P.J., and Stewart, L.J. BMC
Structural Biology
(2011)
11:39
(PDF).
PMID: 21995815.
Structural Genomics of Infectious Disease Drug Targets: The SSGCID.
Stacy, R., Begley, D., Staker, B.L., Phan, I., Van Voorhis, W.C.,
Varani, G., Buchko, G. W., Stewart, L., and Myler, P.J. Acta Cryst.
(2011)
F67, 9:979-984 (PDF). (Complete
SSGCID Special Issue). PMID: 21904037.
Gene Composer in a structural genomics environment.
Lorimer, D., Raymond, A., Mixon, M., Burgin, A., Staker., B., and
Stewart L. Acta Cryst. (2011)
F67, 9:985-991 (PDF).(Complete
SSGCID Special Issue). PMID: 21904038.
Gene design, cloning, and protein expression methods for high-value
targets at the Seattle Structural Genomics Center of Infectious
Disease.
Raymond, A., Haffner, T., Ng, N., Lorimer, D., Staker, B., and
Stewart, L. Acta Cryst. (2011)
F67, 9:992-997 (PDF).(Complete
SSGCID Special Issue). PMID: 21904039.
Immobilized metal affinity chromatography protein recovery screening
is predictive of crystallography structure success.
Choi, R., Kelley, A., Leibly, D., Hewitt, S.N., Napuli, A.J., and
Van Voorhis, W.C. Acta Cryst. (2011)
F67, 9:998-1005 (PDF).(Complete
SSGCID Special Issue). PMID: 21904040.
Expression of proteins in
Escherichia coli as fusions with maltose binding protein to rescue
non-expressed targets in a high-throughput protein expression and
purification pipeline.
Hewitt, S.N., Choi, R., Kelley, A., Crowther, G.J., Napuli, A.J.,
and Van Voorhis, W.C. Acta Cryst. (2011)
F67,
9:1006-1009 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904041.
High-throughput protein production and purification at the Seattle
Structural Genomics Center of Infectious Disease.
Bryan, C., Bhandari, J., Napuli, A.J., Leibly, D., Choi, R., Kelley,
A., Van Voorhis, W.C., Edwards, T.E., and Stewart L.J. Acta Cryst.
(2011)
F67,
9:1010-1014 (PDF).
(Comlete
SSGCID Special Issue). PMID: 21904042.
The Protein Maker: An automated
system for high throughput parallel purification.
Smith, E.R., Begley, D.W., Anderson, V., Raymond, A.C., Haffner, T.E.,
Robinson, J.I., Edwards, T.E., Duncan, N., Gerdts, C.J., Mixon, M.B.,
Nollert, P., Staker, B.L. and Stewart L.J. Acta Cryst. (2011)
F67,
9:1015-1021 (PDF).(Complete
SSGCID Special Issue). PMID: 21904043.
Salvage and storage of infection disease proteins targets in the
SSGCID high throughput crystallization pathway wsing microfluidics.
Christensen, J., Gerdts, C., Clifton, M., and Stewart L. Acta Cryst.
(2011)
F67, 9:1022-1026 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904044.
Rescue of insoluble prokaryotic
proteins using the wheat germ cell-free expression system.
Guild, K., Anderson-Green, A., Benbow, S., Mundt, E., Stacy, R., and
Myler, P.J. Acta Cryst. (2011)
F67,
9:1027-1031 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904045.
Structure of phosphopantetheine
adenylyltransferase from Burkholderia pseudomallei in complex
with hydrolyzed coenzyme A.
Edwards, T.E., Leibly, D.J., Bhandari, J. Statnekov, J.B., Phan, I.,
Dieterich, S.H., Abendroth, J., Staker, B.L. Van Voorhis, W.C.,
Myler, P.J., and Stewart, L.J. Acta Cryst. (2011)
F67, 1032-1037 (PDF).(Complete
SSGCID Special Issue). PMID: 2190404.
Structures of a putative zeta class glutathione-S-transferase from
the pathogenic fungus Coccidioides immitis.
Edwards, T.E., Bryan, C.M., Leibly, D.J., Dieterich, S.H.,
Abendroth, J., Sankaran, B., Sivam, D., Staker, B.L., Van Voorhis,
W.C., Myler, P.J., and Stewart, L.J. Acta Cryst. (2011)
F67,
9:1038-1043 (PDF).(Complete
SSGCID Special Issue). PMID: 21904047.
An ensemble of structures of Burkholderia pseudomallei
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.
Davies, D., Staker, B., Abendroth, J., Edwards, T., Hartley, R.,
Leonard, J., Kim, H., Rychel, A.L., Hewitt, S.N., Myler, P.J., and
Stewart, L.J. Acta Cryst. (2011)
F67,
9:1044-1050 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904048.
Structure of fructose bisphosphate aldolase from Bartonella
henselae, bound to fructose 1,6-bisphosphate.
Gardberg, A., Abendroth, J., Bhandari, B., Sankaran, B., and Staker,
B. Acta Cryst. (2011)
F67,
9:1051-1054 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904049.
The crystal structure of fructose bisphosphate aldolase from
Encephalitozoon cuniculi.
Gardberg, A., Sankaran, B., Davies, D., Bhandari, J., Staker, B.,
and Stewart L. Acta Cryst. (2011)
F67,
9:1055-1059 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904050.
Probing conformational states of gutaryl CoA dehydrogenase by
fragment screening.
Begley, D.W., Davies, D.R., Hartley, R.C., Hewitt, S.N., Rychel, A.L.,
Myler, P.J., Van Voorhis, W.C., Staker, B.L., and Stewart, L.J. Acta
Cryst. (2011)
F67, 1060-1069 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904051.
Inhibitor-bound complexes of dihydrofolate reductase-thymidylate
synthase from Babesia bovis.
Begley, D.W., Edwards, T.E., Raymond, A.C., Smith, E.R., Hartley,
R.C., Abendroth, J., Sankaran, B., Lorimer, D.D., Myler, P.J.,
Staker, B.L., and Stewart, L.J. Acta Cryst. (2011)
F67,
9:1070-1077 (PDF).
PMID: 21904052.
Crystal structure of a Nudix hydroylase (MutT) in the Mg2+ bound
state from Bartonella henselae, the bacterium responsible for
cat scratch fever.
Buchko, G.W., Edwards, T.E., Abendroth, J., Arakaki, T.L., Law, L.,
Napuli, A.J., Hewitt, S.N., Van Voorhis, W.C.,Stewart, L.J., Staker,
B.L., and Myler, P.J. Acta Cryst. (2011)
F67, 9:1078-1083 (PDF).(Complete
SSGCID Special Issue). PMID: 21904053.
Structure of a cyclin-dependent kinase from Giardia lamblia.
Leibly, D.J., Newling, P.A., Abendroth, J., Guo, W., Kelley, A.,
Stewart, L.J., and Van Voorhis W.C. Acta Cryst. (2011)
F67,
9:1084-1089 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904054.
Structure of the thymidylate kinase from Ehrlichia chaffeensis.
Leibly, D.J., Abendroth, J., Bryan, C.M., Sankaran, B., Kelley, A.,
Barrett, L.K., Stewart, L., and Van Voorhis W.C. Acta Cryst. (2011)
F67, 9:1090-1094 (PDF).(Complete
SSGCID Special Issue). PMID: 21904055.
Structure of triosephosphate
isomerase from Cryptosporodium parvum.
Nguyen, T.N., Abendroth, J., Leibly, D.J., Le, K.P., Guo, W.,
Kelley, A., Stewart, L.J., Myler, P.J., and Van Voorhis, W.C. Acta
Cryst. (2011)
F67,
9:1095-1099 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904056.
Structure of nitrilotriacetate monooxygenase component B from
Mycobacterium thermoresistibile.
Zhang, Y., Edwards, T.E., Begley, D., Abramov, A., Thompkins, K.B.,
Ferrell, M., Guo, W.J., Phan, I., Olsen, C., Napuli, A., Sankaran,
B., Stacy, R., Van Voorhis, W.C., Stewart, L.J., and Myler, P.J. Acta
Cryst. (2011)
F67,
9:1100-1105 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904057.
BrabA.11339.a – anomalous diffraction and ligand binding guide
towards the elucidation of the function of a ‘putative beta-lactmase
like protein’ from Brucella melitensis.
Abendroth, J., Sankaran, B., Edwards, T.E., Gardberg, A.S.,
Dieterich, S., Bhandardi, J., Napuli, A.J., Van Voorhis, W.C.,
Staker, B.L., Myler, P.J., Stewart, L.J. Acta Cryst. (2011)
F67,
9:1106-1112 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904058.
Structure of aldose reductase from Giardia lamblia.
Ferrell, M., Abendroth, J., Zhang, S., Sankaran, B., Edwards, T.E.,
Staker, B.L, Van Voorhis, W.C., Stewart, L.J., and Myler, P.J. Acta
Cryst. (2011)
F67,
9:1113-1117 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904059.
Crystal Structure of 3-ketoacyl-(acyl-carrier-protein) reductase
from Rickettsia prowazekii at 2.25 Ångström Resolution.
Subramanian, S., Abendroth, J., Phan, I.Q.H., Olsen, C., Staker, B.L.,
Napuli, A., Van Voorhis, W.C., Stacy, R., and Myler, P.J. Acta Cryst.
(2011)
F67,
9:1118-1122 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904060.
Structure of fumarate hydratase from Rickettsia prowazekii,
the agent of typhus and suspected relative of the mitochondria.
Phan, I., Subramanian, S., Olsen, C., Edwards, T.E., Guo, W., Zhang,
S., Van Voorhis, W.C., Stewart L., and Myler P.J. Acta Cryst. (2011)
F67,
9:1123-1128 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904061.
Solution structure of an arsenate reductase-related protein, YffB,
from Brucella melitensis, the etiological agent responsible
for brucellosis.
Buchko, G.W., Hewitt, S.N., Napuli, A.J., Van Voorhis, W.C., and
Myler, P.J. Acta Cryst. (2011)
F67,
9:1129-1136 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904062.
NMR structure of an acyl carrier protein from Borrelia
burgdorferi.
Barnwal, R.P., Van Voorhis, W.C., and Varani, G. Acta Cryst. (2011)
F67,
9:1137-1140 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904063.
Comparative analysis of glutaredoxin domains from bacterial
opportunistic pathogens.
Leeper, T., Zheng, S., Van Voorhis, W., Myler, P.J., and Varani, G.
Acta Cryst. (2011)
F67, 9:1141-1147 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904064.
Solution-state NMR structure and biophysical characterization of
zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium
tuberculosis.
Buchko, G.W., Hewitt, S.N., Napuli, A.J., Van Voorhis, W.C., and
Myler, P.J. Acta Cryst. (2011)
F67, 9:1148-1153 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904065.
Structure of Cystathionine
gamma-synthase MetB from Mycobacterium ulcerans.
Clifton, M.C., Abendroth, J., Edwards, T., Leibly, D.J., Gillespie,
A.K., Ferrell, M., Dieterich, S.H., Exley, B., Staker, B.L., Myler,
P.J., Van Voorhis, W.C., and Stewart L.J. Acta Cryst. (2011)
F67,
9:1154-1158 (PDF).
(Complete
SSGCID Special Issue). PMID: 21904066.
Structural basis of substrate specificity of bifunctional
isocitrate dehydrogenase kinase/phosphatase.
Yates, S.P., Edwards, T.E., Bryan, C.M., Stein, A.J., Van Voorhis,
W.C., Myler, P.J., Stewart, L.J., Zheng, J., and Jia, Z.
Biochemistry (2011) 50(38):8103-6 (PDF). PMID:
21870819.
Chemical shift assignments for Rv0577, a putative glyoxylase associated with virulence
from Mycobacterium tuberculosis.
Buchko, G.W., Kim, H., Myler, P.J., Terwilliger, T.C., and Kim C.-Y. Biomol NMR Assign (2011)
[Epub ahead of print] (PDF).
PMID:21761124.
The structure of a Burkholderia pseudomallei immunophilin-inhibitor
complex reveals new.
Norville, I., O’Shea, K., Sarkar-Tyson, M., Zheng, S., Titball,
R.W., Varani, G., and Harmer, N.J. Biochem J (2011) 437(3):413-22 (PDF).
PMID:21574961.
Design and initial characterization of the SC-200 Proteomics
Standard Mixture.
Bauman, A., Higdon, R., Rapson, S., Loiue, B., Hogan, J., Stacy,
R., Napuli, A., Guo, W., Van Voorhis, W.C., Roach, J., Lu, V.,
Landorf, E., Stewart, E., Kolker, N., Collart, F., Myler, P.J., van
Belle, G. and Kolker, E. OMICS (2011) 15 (1-2):73-82. (PDF).
PMID:21250827.
Crystal structure of Toxoplasma gondii porphobilinogen synthase:
Insights on octameric structure and porphobilinogen formation.
Jaffe, E.K., Shanmugan, D., Gardberg, A., Dieterich, S.,
Sankaran, B., Stewart, L.J., Myler, P.J., and Roos, D.S.
J Biol Chem (2011) 286(17):15298-307 (PDF).
PMID:21383008.
Fragment screening of infectious disease targets in a structural
genomics environment.
Begley, D.W., Davies, D.R., Hartley, R.C., Edwards, T.E.,
Staker, B.L., Van Voorhis, W.C., Myler, P.J. and Stewart, L.J.
Methods In Enzymology (2011) 493:533-556
(Book
see Ch 4).
Predicting the success of fragment screening by x-ray
crystallography.
Davies, D.R., Begley, D.W., Hartley, R., Staker, B.L. and
Stewart, L.J. Methods In Enzymology (2011) 493:91-114 (Book
See Ch 21).
SAD phasing using iodide ions in a high-throughput structural
genomics environment.
Abendroth, J., Gardberg, A.S., Robinson, J.I., Christensen, J.S.,
Staker, B.L., Myler, P.J., Stewart, L.J., and Edwards, T.E. J Struct
Funct Genom (2011) [12(2):83-95] (PDF).
PMID: 21359836.
Leveraging structure determination with fragment screening for
infectious disease drug targets: MECP synthase from Burkholderia
pseudomallei.
Begley, D.W., Hartley, R., Davies, D.R., Edwards, T.E., Leonard, J.,
Abendroth, J., Burris, C., Bhandari, J., Myler, P.J., Staker, B.L.
and Stewart, L.J. J Struct Funct Genom (2011) [12(2):63-76] (PDF)
PMID: 21359640.
Crystal structure of the receptor binding domain of the botulinum
C–D mosaic neurotoxin reveals potential roles of lysines 1118 and
1136 in membrane interactions.
Zhang Y, Buchko GW, Qin Q, Robinson H and Varnum SM. Biochem
Biophys Res Comm (2010) 404:407-412 (PDF).
PMID: 21130733.
Inaugural structure from the DUF3349 superfamily of proteins,
Mycobacterium tuberculosis Rv0543c.
Buchko GW, Phan I, Myler PJ, Terwilliger TC and Kim CY. Arch
Biochem Biophys (2010) [506(2):150-6] (PDF).
PMID: 21144816.
Nanovolume optimization of protein crystal growth using the
microcapillary protein crystallization system.
Gerdts CJ, Stahl GL, Napuli A, Staker B, Abendroth J, Edwards
TE, Myler P, Van Voorhis W, Nollert P and Stewart LJ. J Appl Cryst
(2010) 43:1078-1083
PDF.
Structure of a Burkholderia pseudomallei Trimeric
Autotransporter Adhesin Head.
Edwards TE, Phan I, Abendroth J, Dieterich SH, Masoudi A, Guo W,
Hewitt SN, Kelley A, Leibly D, Brittnacher MJ, Staker BL, Miller SI,
Van Voorhis WC, Myler PJ, Stewart LJ. PLoS One (2010) 5(9):e12803 (PDF). PMID:
20862217.
Biological and structural characterization of a host-adapting
amino acid in influenza virus.
Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, Shinya K,
Sakai-Tagawa Y, Ito M, Ozawa M, Watanabe T, Sakabe S, Li C, Kim JH,
Myler PJ, Phan I, Raymond A, Smith E, Stacy R, Nidom CA, Lank SM,
Wiseman RW, Bimber BN, O’Connor DH, Neumann G, Stewart LJ, Kawaoka
Y. PLoS Pathogens (2010) 6(8): e1001034.
PDF. PMID:
20700447.
Solution structure of Rv2377c-founding member of the MbtH-like
protein family.
Buchko GW, Kim CY, Terwilliger TC, Myler PJ.
Tuberculosis (2010) 90,245-251 PDF.
PMID: 20434955.
X-ray structure determination of the glycine cleavage system
protein H of Mycobacterium tuberculosis using an inverse
Compton synchrotron X-ray source.
Abendroth J, McCormick MS, Edwards TE, Staker B, Loewen R, Gifford
M, Rifkin J, Mayer C, Guo W, Zhang Y, Myler PJ, Kelley A, Analau E,
Nakazawa Hewitt S, Napuli A, Kuhn P, Ruth RD and Stewart LJ .
Struct Funct Genomics (2010) 11:91-100
PDF. PMID:
20364333.
The Structural characterization of Burkholderia pseudomallei
adenylate kinase (Adk): Profound asymmetry in the crystal structure
of the ‘open’ state.
Buchko GW, Robinson H, Abendroth J, Staker BL, Myler PJ. Biochem
Bioph Res Comm (2010) 394:1012–1017
PDF. PMID:
20331978.
The Role of Medical Structural Genomics in Discovering New Drugs
for Infectious Diseases.
Van Voorhis WC, Hol WGJ,
Myler PJ, Stewart L. PLoS Comp Biol (2009) 5(10):e1000530.
PDF. PMID:
19855826.
The Seattle Structural Genomics Center for Infectious Disease
(SSGCID).
Myler PJ, Stacy R, Stewart L, Staker B, Van Voorhis WC, Varani G,
Buchko GW. Infect Disorders - Drug Targets (2009) 9(5):493-506.
PDF. PMID:
19594426.
Backbone and side chain 1H, 13C, and 15N NMR assignments for the
organic hydroperoxide resistance protein (Ohr) from Burkholderia
pseudomallei.
Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Biomol
NMR Assign. (2009) 3:163-166.
PDF.
PMID: 19888681.
Combined protein construct and synthetic gene engineering for
heterologous protein expression and crystallization using Gene
Composer.
Raymond A, Lovell S, Lorimer D, Walchli J, Mixon M, Wallace E,
Thompkins K, Archer K, Burgin A, Stewart L. BMC Biotechnol. (2009) 9:37.
PDF. PMID:
19383143.
The plug-based nanovolume Microcapillary Protein Crystallization
System (MPCS). Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli
AJ, Staker BL, Nollert P, Stewart L. Acta Crystallogr D Biol
Crystallogr. (2008) 64(Pt 11):1116-22.
PDF. PMID:
19020349.
Publications by SSGCID
collaborators
Publishing structural genomics results continued: the
SSGCIDSpecial Issue.
Weiss, M.S., and Einspahr, H. Acta Cryst F (2011) F67:1159.
PDF.
Editorial.
User-loaded SlipChip for equipment-free multiplexed nanoliter-scale
experiments.
Li L, Du W, Ismagilov R.J Am Chem Soc. (2010) 132(1):106-11.
PDF.
PMID: 20000708.
Multiparameter screening on SlipChip used for nanoliter protein
crystallization combining free interface diffusion and microbatch
methods.
Li L, Du W, Ismagilov RF. J Am Chem Soc. (2010) 132(1):112-9.
PDF.
PMID: 20000709.
Phospholipid-binding protein EhC2A mediates calcium-dependent
translocation of transcription factor URE3-BP to the plasma membrane
of Entamoeba histolytica.
Moreno H, Linford AS, Gilchrist CA, Petri WA Jr. Eukaryot Cell.
(2010) 9(5):695-704.
PDF. PMID
20023071.
Editorials by SSGCID
Structural Genomics- A goldmine of blueprints for
structure-based drug design.
Buchko, G.W. Metabolomics (2011) 1(2):epub. (PDF).
Editorial.
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