Seattle Structural Genomics Center for Infectious Disease

MbtH Rv2377c

  • Cartoon representation of Rv2377c structureMbtH Protein Rv2377c:
    The depicted structure represents the protein Rv2377c from Mycobacterium tuberculosis, the pathogenic bacterial species that is the causative agent of most cases of tuberculosis.  Rv2377c is the founding member of the MtbH family of proteins that are located in a cluster of genes involved in nonribosomal peptide synthesis of mycobactin. While the precise biological function of Rv2377c and other MbtH-like proteins remain unknown, their association with siderophore biosynthesis has identified these proteins as a target for antibiotic development because siderophores are crucial to iron regulation in the bacterium after infection. For more information, please see the Protein Data Bank entry 2khr.