Seattle Structural Genomics Center for Infectious Disease


The Seattle Structural Genomics Center for Infectious Disease, SSGCID is one of two CRSTAL-ID Centers funded by NIAID, and is based in Seattle, WA. The other funded center (CSBID) is based out of Chicago, IL. Both centers provide structural biology expertise to the infectious disease research community. The centers were each formed in 2007 and are currently operating under contracts in response to RFP 75N93021R00009. SSGCID is a consortium of six institutions (Seattle Children's Research Institute, Dartmouth College, University of Washington, University of Kansas, Washington University in St. Louis, and Washington State University). 

Management of the SSGCID is overseen by a Scientific Leadership Team comprised of the primary Principal Investigator (from Seattle Children's Research Institute) and the Principal Investigators from the sub-contracting institutions (Dartmouth College, University of Kansas, University of Washington, Washington University in St. Louis, and Washington State University), with the assistance of an overall Project Manager and Site Managers at each site.

Activities within the SSGCID project are divided into seven teams distributed between the sites:

  • Project Management Team
  • IT & Data Management Team
  • Target Selection Team
  • Cloning & Expression Testing Team
  • Protein Production Team
  • Crystallization Team
  • Data Collection & Structure Solution Team

The Scientific Advisory Board makes recommendations to the CRSTAL-ID Centers on efficiently generating protein structures in a high throughput environment, provides advice on the structural biology needs of the scientific community, makes recommendations on priority targets to pursue, and otherwise advises the CRSTAL-ID Centers. The members of the Scientific Advisory Board have been recruited from among eminent scientists outside of the SSGCID and CSBID and include members that provide a broad domain representation of the relevant scientific community.