Seattle Structural Genomics Center for Infectious Disease

Spike from SARS-CoV-2

The outbreak of coronavirus SARS-CoV-2 (2019-nCoV), which causes COVID-19, was first reported from Wuhan, China on 31 December 2019.  The World Health Organization declared a global emergency and the SSGCID prioritized structural genomic efforts to focus on the elucidation of important protein structures of SARS-CoV-2, with emphasis on the Spike protein.

  • The UW-CryoEM team determined the structure, function, and antigenicity of the Spike protein.  Read the original article published in Cell
  • The UW-CryoEM team continues to study the structure of the Spike protein from SARS-CoV-2 variants and how those variants affect immunity. These include studies on Omicron, antigenic mapping, and B.1.427/B.1.429 published in Nature, Cell and Science, respectively.

The structure of Spike in closed formation from SARS-CoV-2.