Functional Studies

Target Functional Characterization Projects

The SSGCID carries out up to three projects each year to utilize experimental approaches to functionally characterize the molecular role of proteins targets whose structure was determined within the Center's pipeline. Brief descriptions and final reports for completed projects are described below.

FUN_16: Bioaffinity Mass Spectrometry Small Molecule Screening of Mycobacterium Targets.
Project completed

FUN_15: Identification of host-pathogen interactions by chemical crosslinking and mass-spectrometry.
Project completed

FUN_14: Generation of inhibitors of Acetyl-CoA Synthetase from pathogenic fungi.
Project completed

FUN_13: Characterization and elaboration of fragment compounds against Ebola matrix proteins.
Project completed

FUN_12: The role of MbtH-like proteins in nonribosomal peptides synthetase (NRPS) assembly-lines: Tools for biosynthesis/bioengineering of novel antibiotics.
Project completed

FUN_11: Functional characterization of PfHMGB2 and development as a drug target for the treatment of Cerebral Malaria.
Project completed

FUN_10: Characterization of a mycobacterial signaling scaffold involved in pathogenesis.
Project completed

FUN_09: Evaluation of the Inhibitory Activity of Small Molecule Compounds Against Rickettsia prowazekii Methionine Aminopeptidase (MetAp) using in vitro & in vivo Assays
Project completed

FUN_08: Mycobacterium cytidylate kinases: drug target for tuberculosis and proof-of-concept for the mycobacteria ortholog approach
Project completed

FUN_07: Characterization and elaboration of fragment compounds against Influenza A virus polymerase
Project completed

FUN_06: Identification of the biological stimulant for the periplasmid domain of the B. pseudomallei histidine kinase RisS
Project completed

FUN_05: Use of the SSGCID solved structure of B. melitensis methionine tRNA-synthetase (MetRS) to find inhibitors for potential drug development forbrucellosis
Project completed

FUN_04: Functional evaluation of M. tuberculosis Rv2179c, the founding member of a new ribonuclease family
Project completed

FUN_03: Role and funciton of M. tuberculosis protein Rv0577
Project completed

FUN_01: Function of bacterial immunophilins for antibiotic discovery
Project completed