SSGCID
Seattle Structural Genomics Center for Infectious Disease

Special Projects

Special Projects

Each year, SSGCID carries out six special projects. Currently, two of these projects are focused on determining the function of a protein that has already had its structure determined, two are focused on structure-based development of a product that could be used to combat disease, and two are focused on pandemic preparation/rapid response to outbreaks.

These projects are proposed by members of SSGCID, reviewed and commented on by our scientific advisory board, then reviewed by our contracting officer. These projects are often conducted with external collaborators and allow SSGCID to perform research that goes beyond the structural biology to gain understanding about the diseases of interest.



The following projects are currently being pursued:

  • Structure and functional studies of RsbU from Chlamydia 
  • Structural characterization of Pseudomonas aeruginosa glutamyl tRNA synthetase (PaGluRS) and related GluRSs
  • Dual MurC & MurD ligase inhibitors as antibacterials
  • Rescue of insoluble high value targets by minibinder stabilization
  • Computational design of stabilized Nipah virus attachment and fusion glycoproteins
  • Structural characterization of an essential RNA packaging element from the Influenza A Virus