SSGCID
Seattle Structural Genomics Center for Infectious Disease
SSGCID
The primary mission of SSGCID and our sister center CSBID
is to determine the 3D atomic structures of proteins and other molecules with an important
biological role in human pathogens themselves, or molecules involved in host-pathogen interactions, by applying
state-of-the art high-throughput (HTP) technologies and methodologies. Pathogens include those on the NIAID Category
A-C agents as well as emerging and re-emerging infectious disease organisms, each year for a period of five years.
This program will also support research projects that utilize experimental approaches to better characterize the
molecular mechanisms of protein targets and gain further insight into the functional roles of these targets.
Inorganic pyrophosphatase from Legionella pneumophila.
Structure solved and published by students advised by Krystle Mclaughlin
in collaboration with SSGCID, highlighted by the journal editor.
Organisms studied
Bacteria
- Actinobacteria ( Mycobacterium )
- Alpha-proteobacteria ( Anaplasma, Bartonella, Brucella, Ehrlichia, Rickettsia )
- Bacilli ( Bacillus, Enterococcus, Listeria, Staphylococcus, Streptococcus )
- Beta-proteobacteria ( Burkholderia )
- Chlamydiae ( Chlamydia )
- Clostridia ( Clostridium )
- Epsilon-proteobacteria ( Campylobacter, Helicobacter )
- Gamma-proteobacteria ( Coxiella, Escherichia, Francisella, Legionella, Salmonella, Shigella, Stenotrophomonas, Vibrio, Yersinia, )
- Spirochaetes ( Borrelia, Leptospira )
Eukaryota
- Eukaryotic pathogens ( Absidia, Acanthamoeba, Aspergillus, Babesia, Balamuthia, Coccidioides, Cryptococcus, Cryptosporidium, Cunninghamella, Cyclospora, Encephalitozoon, Entamoeba, Giardia, Mucor, Naegleria, Rhizopus, Toxoplasma)
Viruses
- dsDNA viruses ( BK virus, JC virus, Orthopoxvirus, Rhadinovirus, Roseolovirus )
- ssDNA virus (Erythrovirus)
- ssRNA negative-strand viruses ( Arenavirus, Ebola-like viruses, Hantavirus, Henipavirus, Influenzavirus, Lyssavirus A, Marburgvirus, Measles virus, Nairovirus, Orthobunyavirus, Phlebovirus, Rubulavirus )
- ssRNA positive-strand viruses ( Alphavirus, Coronaviruses incl. Betacoronavirus, Enterovirus, Flavivirus incl Zika, Hepacivirus, Hepatovirus, Hepevirus, Lagovirus, Norovirus, Sapovirus, Vesivirus )
Publish our structures
We are looking for authors to drive publication of any of our structures.
Want to be first/last author? You can!
Participating institutions
